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Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B AMPA AMPA Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Sodium channel subunit beta-1 Vesicular glutamate transporter 3 Gabapentin Glutamate Ca+ Na+ Na+ Na+ Ca+ Ca+ Glutamate Glutamate Ca+ Na+ Gabapentin Gabapentin Neuronal Excitability Sodium channel protein type 10 subunit alpha When an action potential arrives at the nerve terminal, it activates voltage gated calcium channels Influx of calcium triggers the release of excitatory neurotransmitter, glutamate, into the synaptic cleft Gabapentin inhibits the α2δ-1 subunit of voltage-gated calcium channels, preventing neurotransmitter release and reducing excitation of the post-synaptic neuron Glutamate activates AMPA and NMDA receptors on the post-synaptic neuron, causing excitation of the post-synaptic neuron Synaptic Vesicle Presynaptic Neuron Synapse Postsynaptic Neuron Gabapentin is administered as an oral capsule
CACNA2D1 CACNA2D2 CACNA1B GRIA1 GRIA2 GRIN1 GRIN2A GRIN3A SCN1B SLC17A8 Gabapentin Glutamate Calcium Sodium Sodium Sodium Calcium Calcium Glutamate Glutamate Calcium Sodium Gabapentin Gabapentin Neuronal Excitability SCN10A
CACNA2D1 CACNA2D2 CACNA1B GRIA1 GRIA2 GRIN1 GRIN2A GRIN3A SCN1B SLC17A8 Acloniu Gluta Ca+ Na+ Na+ Na+ Ca+ Ca+ Gluta Gluta Ca+ Na+ Acloniu Acloniu Neu Exc SCN10A When an action potential arrives at the nerve terminal, it activates voltage gated calcium channels Influx of calcium triggers the release of excitatory neurotransmitter, glutamate, into the synaptic cleft Gabapentin inhibits the α2δ-1 subunit of voltage-gated calcium channels, preventing neurotransmitter release and reducing excitation of the post-synaptic neuron Glutamate activates AMPA and NMDA receptors on the post-synaptic neuron, causing excitation of the post-synaptic neuron Synaptic Vesicle Presynaptic Neuron Synapse Postsynaptic Neuron Gabapentin is administered as an oral capsule
CACNA2D1 CACNA2D2 CACNA1B GRIA1 GRIA2 GRIN1 GRIN2A GRIN3A SCN1B SLC17A8 Acloniu Gluta Ca2+ Na+ Na+ Na+ Ca2+ Ca2+ Gluta Gluta Ca2+ Na+ Acloniu Acloniu Neu Exc SCN10A