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Oxytocin receptor Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 3 Myosin light chain kinase, smooth muscle Protein kinase C Mitogen- activated protein kinase 1 Mitogen- activated protein kinase 3 Cytosolic phospholipase A2 Transforming protein RhoA Rho-associated protein kinase 1 Gq protein signaling cascade Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Myosin light chain 3 Calmodulin-1 Myosin LC-P Myosin light chain phosphatase CPI-17 CPI-17-P Myosin light chain phosphatase-P Actin, cytoplasmic 1 Calmodulin-1 Actin, cytoplasmic 1 Myosin light chain 3 Oxytocin Inositol 1,4,5-trisphosphate Ca+ Ca+ Ca+ Ca+ Phosphatidylinositol 4,5-bisphosphate Calcium Magnesium Calcium Calcium Magnesium Magnesium Manganese Manganese Ca+ Diacylglycerol Muscle Relaxation Prostaglandin Synthesis Muscle Contraction Myometrial Cell Sarcoplasmic Reticulum Cytosol Oxytocin activates the oxytocin receptor on the myometrial cell leading to activation of the Gq signaling cascade Gq signaling cascade activates phospholipase C which produces IP3 and DAG IP3 activates IP3 receptor on the sarcoplasmic reticulum, leading to calcium moving from the sarcoplasmic reticulum to the cytosol, increasing cytosolic calcium concentration Calcium also enters the cell through the L-type calcium channel on the cell membrane, which is activated downstream after activation of the oxytocin receptor Calcium binds to calmodulin activating myosin light chain kinase, leading to phosphorylation of myosin light chain Phosphorylated myosin light chain binds to actin to form an actinomyosin complex which causes smooth muscle contraction Muscle contraction The RhoA protein and protein kinase C can also lead to the inactivated, phosphorylated form of myosin light chain phosphatase, preventing the conversion of myosin-LC-P to Myosin-LC Protein kinase C leads to prostaglandin synthesis. Prostaglandins like E2 stimulates uterine contraction Oxytocin is taken intravenously or intramuscularly
OXTR Gq protein signaling cascade PLCB1 ITPR3 MYLK PRKCA MAPK1 MAPK3 PLA2G4A RHOA ROCK1 Gq protein signaling cascade CACNA1A CACNB1 CACNA2D2 MYL3 CALM1 MYL3 PPP1CB PPP1R14A PPP1R14A PPP1CB ACTB CALM1 ACTB MYL3 Oxytocin Inositol 1,4,5- trisphosphate Calcium Calcium Calcium Calcium Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Relaxation Prostaglandin Synthesis Muscle Contraction
OXTR GNAQ PLCB1 ITPR3 MYLK PRKCA MAPK1 MAPK3 PLA2G4A RHOA ROCK1 GNAQ CACNA1A CACNB1 CACNA2D2 MYL3 CALM1 MYL3 PPP1CB PPP1R14A PPP1R14A PPP1CB ACTB CALM1 ACTB MYL3 Oxt Inotp Ca+ Ca+ Ca+ Ca+ P45P Ca2+ Mg2+ Ca2+ Ca2+ Mg2+ Mg2+ Mn2+ Mn2+ Ca+ Diacylg Mus Rel Pro Syn Mus Con Myometrial Cell Sarcoplasmic Reticulum Cytosol Oxytocin activates the oxytocin receptor on the myometrial cell leading to activation of the Gq signaling cascade Gq signaling cascade activates phospholipase C which produces IP3 and DAG IP3 activates IP3 receptor on the sarcoplasmic reticulum, leading to calcium moving from the sarcoplasmic reticulum to the cytosol, increasing cytosolic calcium concentration Calcium also enters the cell through the L-type calcium channel on the cell membrane, which is activated downstream after activation of the oxytocin receptor Calcium binds to calmodulin activating myosin light chain kinase, leading to phosphorylation of myosin light chain Phosphorylated myosin light chain binds to actin to form an actinomyosin complex which causes smooth muscle contraction Muscle contraction The RhoA protein and protein kinase C can also lead to the inactivated, phosphorylated form of myosin light chain phosphatase, preventing the conversion of myosin-LC-P to Myosin-LC Protein kinase C leads to prostaglandin synthesis. Prostaglandins like E2 stimulates uterine contraction Oxytocin is taken intravenously or intramuscularly
OXTR GNAQ PLCB1 ITPR3 MYLK PRKCA MAPK1 MAPK3 PLA2G4A RHOA ROCK1 GNAQ CACNA1A CACNB1 CACNA2D2 MYL3 CALM1 MYL3 PPP1CB PPP1R14A PPP1R14A PPP1CB ACTB CALM1 ACTB MYL3 Oxt Inotp Ca2+ Ca2+ Ca2+ Ca2+ P45P Ca2+ Diacylg Mus Rel Pro Syn Mus Con