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Nitric oxide
synthase,
endothelial
Y+L amino acid
transporter 1
SLC3A2/4F2hc
Y+L amino acid
transporter 1
Low affinity
cationic amino
acid
transporter 2
Low affinity
cationic amino
acid
transporter 2
Protein
arginine N-
methyltransferase
1
Asymmetrical dimethylarginine
L-Arginine
L-Arginine
Asymmetrical dimethylarginine
L-Arginine
L-Arginine
L-Arginine
S-Adenosylmethionine
S-Adenosylhomocysteine
Endothelial
dysfunction &
atherosclerosis
Intestinal Lumen
Intestinal epithelial cells
Intestinal epithelial cells
L-arginine obtained from
protein-rich foods like
meat, fish, poultry, dairy
and eggs
Cytosol
Hepatocyte
NOS3
SLC7A7
SLC3A2
SLC7A2
SLC7A2
PRMT1
Asymmetrical
dimethylarginine
L-Arginine
L-Arginine
Asymmetrical
dimethylarginine
L-Arginine
L-Arginine
L-Arginine
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Endothelial
dysfunction &
atherosclerosis