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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Lorazepam L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Lorazepam Lorazepam Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA A receptor in between the alpha and beta subunits. This causes the chloride channel to open causing hyper-polarization in the post synaptic neuron suppressing signalling. Lorazepam binds to an allosteric site of the GABA A receptor between the gamma and alpha subunits. This also causes the chloride channel to open more frequently causing hyper-polarization in the post synaptic neuron further suppressing signalling. Cytosol Cytosol Synapse Lorazepam is administered as an oral tablet
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Lorazepam L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Lorazepam Lorazepam Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Ativan Glu Cl- GABA Ca+ Ativan Ativan Cl- CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Hyper Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA A receptor in between the alpha and beta subunits. This causes the chloride channel to open causing hyper-polarization in the post synaptic neuron suppressing signalling. Lorazepam binds to an allosteric site of the GABA A receptor between the gamma and alpha subunits. This also causes the chloride channel to open more frequently causing hyper-polarization in the post synaptic neuron further suppressing signalling. Cytosol Cytosol Synapse Lorazepam is administered as an oral tablet