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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Cytochrome P450 2D6 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Multidrug resistance- associated protein 4 Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Glutethimide Glutethimide L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Morphine Morphine Glutethimide Glutethimide Cl- CO2 ATP PPi Codeine Heme Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(A) receptor in between the alpha and beta subunits. Glutethimide binds to an allosteric site of the GABA(A) receptor between the gamma and alpha subunits. Cytosol Cytosol Synapse Hepatocyte Glutethimide induces CYP 2D6 which when taken with codeine converts higher amounts of codeine to morphine. Endoplasmic Reticulum Glutethimide is administered as an oral tablet
Endoplasmic Reticulum GABRB2 GABRG2 GABBR2 GABRA1 CYP2D6 ADCY1 SLC32A1 CACNA1A ABCC4 GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Glutethimide Glutethimide L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Morphine Morphine Glutethimide Glutethimide Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Codeine Gi/o signalling Glutamate Metabolism Hyperpolarization