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Gamma-
aminobutyric
acid receptor
subunit beta-2
Gamma-
aminobutyric
acid receptor
subunit gamma-2
Gamma-
aminobutyric
acid type B
receptor
Gamma-
aminobutyric
acid receptor
subunit alpha-1
Adenylate
cyclase type 1
Vesicular
inhibitory
amino acid
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Glutamate
decarboxylase 1
γ-Aminobutyric acid
cAMP
γ-Aminobutyric acid
Ca
+
Nitrazepam
L-Glutamic acid
Cl
-
γ-Aminobutyric acid
Ca
+
Nitrazepam
Nitrazepam
Cl
-
CO
2
ATP
PP
i
Magnesium
Pyridoxal
5'-phosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
Hyperpolarization leading to
reduced depolarization and
excitability. Decreasing
neuronal excitability has a
sedative effect
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA binds to the GABA(A)
receptor in between the
alpha and beta subunits.
Nitrazepam binds to the
GABA(A) receptor at the
benzodiazepine binding site
to enhance GABA binding
activity.
Cytosol
Cytosol
Synapse
Nitrazepam is administered
as an oral tablet
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
γ-Aminobutyric
acid
cAMP
γ-Aminobutyric
acid
Calcium
Nitrazepam
L-Glutamic acid
Chloride ion
γ-Aminobutyric
acid
Calcium
Nitrazepam
Nitrazepam
Chloride ion
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
GABA
cAMP
GABA
Ca
+
Eatan
Glu
Cl
-
GABA
Ca
+
Eatan
Eatan
Cl
-
CO
2
ATP
PP
i
Mg2+
Pyr-5'P
Gi/ sig
PW000003
Hyper
Hyperpolarization leading to
reduced depolarization and
excitability. Decreasing
neuronal excitability has a
sedative effect
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA binds to the GABA(A)
receptor in between the
alpha and beta subunits.
Nitrazepam binds to the
GABA(A) receptor at the
benzodiazepine binding site
to enhance GABA binding
activity.
Cytosol
Cytosol
Synapse
Nitrazepam is administered
as an oral tablet