Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Multidrug resistance- associated protein 4 Solute carrier family 22 member 11 Glutamate decarboxylase 1 Cytochrome P450 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Phenobarbital L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Phenobarbital Phenobarbital Primidone Primidone Primidone Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(a) receptor in between the alpha and beta subunits. Phenobarbital binds to GABA(A) receptor. Cytosol Cytosol Synapse Hepatocyte Endoplasmic Reticulum Primidone is metabolized into phenobarbital by cytochrome P450. Primidone is administered as an oral tablet
Endoplasmic Reticulum GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A ABCC4 SLC22A11 GAD1 CYP2A13 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Phenobarbital L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Phenobarbital Phenobarbital Primidone Primidone Primidone Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization