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Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit 3A Vesicular glutamate transporter 3 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutaminase kidney isoform, mitochondrial L-Glutamic acid Ca+ L-Glutamic acid Esketamine L-Glutamine Ca+ Ca+ L-Glutamic acid Ca+ Esketamine Esketamine H2O NH3 Glutamate Metabolism Hyperpolarization Cytosol Esketamine non-selectively and non-competitively binds to the Glutamate NMDA receptor subunit 2 which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron The low concentration of calcium in the postsynaptic neuron causes hyperpolarization, which increases the membrane potential threshold, preventing depolarization Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Synaptic Vesicle Synapse Esketamine is injected intravenously Blood-Brain Barrier Diffusion
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS L-Glutamic acid Calcium L-Glutamic acid Esketamine L-Glutamine Calcium Calcium L-Glutamic acid Calcium Esketamine Esketamine Water Ammonia Glutamate Metabolism Hyperpolarization
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca+ Glu Esket Gln Ca+ Ca+ Glu Ca+ Esket Esket H2O NH3 PW000003 Hyper Cytosol Esketamine non-selectively and non-competitively binds to the Glutamate NMDA receptor subunit 2 which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron The low concentration of calcium in the postsynaptic neuron causes hyperpolarization, which increases the membrane potential threshold, preventing depolarization Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Synaptic Vesicle Synapse Esketamine is injected intravenously Blood-Brain Barrier Diffusion
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca2+ Glu Esket Gln Ca2+ Ca2+ Glu Ca2+ Esket Esket H2O NH3 PW000003 Hyper