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Pathway Description
Lacidipine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-19
Last Updated: 2023-11-27
Lacidipine is a lipophilic dihydropyridine calcium channel blocker with a slow onset of action used to treat hypertension. Lacidipine is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce blood pressure. Lacidipine is a specific and potent calcium antagonist with a predominant selectivity for calcium channels in the vascular smooth muscle. Its main action is to dilate predominantly peripheral and coronary arteries, reducing peripheral vascular resistance and lowering blood pressure. By blocking the voltage-dependent L-type calcium channels, it prevents the transmembrane calcium influx. Normally, calcium ions serve as intracellular messengers or activators in exictable cells including vascular smooth muscles. The influx of calcium ultimately causes the excitation and depolarization of the tissues. Lacidipine inhibits the contractile function in the vascular smooth muscle and reduce blood pressure. Due to its high membrane partition coefficient, some studies suggest that lacidipine may reach the receptor via a two-step process; it first binds and accumulates in the membrane lipid bilayer and then diffuses within the membrane to the calcium channel receptor. It is proposed that lacidipine preferentially blocks the inactivated state of the calcium channel. Possible side effects of using lacidipine may include dizziness, headache, nausea, and weakness.
References
Lacidipine Pathway References
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Lacidipine Summary of Product Characteristics [http://mri.cts-mrp.eu/download/NL_H_2992_002_FinalSPC.pdf]
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