Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Gamma- aminobutyric acid type B receptor Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Methsuximide L-Glutamic acid γ-Aminobutyric acid Ca+ Ca+ Ca+ Methsuximide Methsuximide CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle Cytosol Cytosol Synapse Methsuximide binds to T-type calcium channels and inhibits calcium influx. It targets the alpha-1G subunit specifically. Hyperpolarization prevents absence seizures GABA release is inhibited due to mutations of the SCN1A, SCN1B gene causing enhanced reuptake Methsuximide is administered as an oral capsule
GABBR2 CACNA1H CACNA1G ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Methsuximide L-Glutamic acid γ-Aminobutyric acid Calcium Calcium Calcium Methsuximide Methsuximide Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization
GABBR2 CACNA1H CACNA1G ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Celonti Glu GABA Ca+ Ca+ Ca+ Celonti Celonti CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Hyper Hyperpolarization leading to reduced depolarization and excitability Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle Cytosol Cytosol Synapse Methsuximide binds to T-type calcium channels and inhibits calcium influx. It targets the alpha-1G subunit specifically. Hyperpolarization prevents absence seizures GABA release is inhibited due to mutations of the SCN1A, SCN1B gene causing enhanced reuptake Methsuximide is administered as an oral capsule