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Myosin light chain kinase, smooth muscle Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Myosin LC-P Myosin light chain 3 Inositol 1,4,5- trisphosphate receptor type 1 Myosin light chain phosphatase Calmodulin Calmodulin Voltage- dependent calcium channel subunit alpha-2/delta-1 Verapamil Ca+ Ca+ Ca+ Ca+ Muscle Contraction Muscle Relaxation G Protein Signalling Cascade Magnesium Calcium Verapamil is taken intravenously Manganese Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Verapamil binds and inhibits calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Dilation Actin Myosin
MYLK CACNB1 CACNA1C MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Verapamil Calcium Calcium Calcium Calcium Muscle Contraction Muscle Relaxation G Protein Signalling Cascade
MYLK CACNB1 CACNA1C MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Verpmil Ca+ Ca+ Ca+ Ca+ Mus Con Mus Rel G P S C Mg2+ Ca2+ Verapamil is taken intravenously Mn2+ Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Verapamil binds and inhibits calcium channels preventing calcium influx Activation or inhibition of the receptors linked to the G protein signalling cascade can alter calcium levels in the cell. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Dilation Actin Myosin
MYLK CACNB1 CACNA1C MYL3 MYL3 ITPR1 PPP1CB CALM1 CALM1 CACNA2D1 Verpmil Ca2+ Ca2+ Ca2+ Ca2+ Mus Con Mus Rel G P S C