Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Beta-1 adrenergic receptor Sodium- dependent noradrenaline transporter Alpha-1A adrenergic receptor Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Multidrug resistance protein 1 Solute carrier organic anion transporter family member 1B1 Solute carrier organic anion transporter family member 1B1 Dopamine beta- hydroxylase Aromatic-L- amino-acid decarboxylase Tyrosine 3-monooxygenase Cytochrome P450 2D6 Norepinephrine Venlafaxine Ca+ Norepinephrine Norepinephrine Ca+ Desvenlafaxine Desvenlafaxine Venlafaxine Venlafaxine Dopamine Ascorbic acid O2 Dehydroascorbic acid H2O L-Dopa CO2 L-Tyrosine Pyrroloquinoline quinone Copper Pyridoxal 5'-phosphate Fe2+ Heme Gq Signalling cascade Mood and Cognition Limbic System Limbic System Brain Cytosol Presynaptic Neuron Desvenlafaxine inhibition causes more norepinephrine to accumulate in the synapse and continual activation of the alpha-1A adrenergic receptor Synapse Synaptic Vesicle Desvenlafaxine is rapidly absorbed from the gastrointestinal tract. Norepinephrine is produced in the locus coeruleus Cytosol In depressed individuals, Alpha A1 and B1 receptors are desensitized leading to changes in cognitive function, fatigue, sleep and immune response. hepatocytes liver endoplasmic reticulum Post Synaptic neuron
Endoplasmic Reticulum ADRB1 SLC6A2 ADRA1A SLC18A2 CACNA2D1 CACNA2D2 CACNA1B ABCB1 SLCO1B1 SLCO1B1 DBH DDC TH CYP2D6 Norepinephrine Venlafaxine Calcium Norepinephrine Norepinephrine Calcium Desvenlafaxine Desvenlafaxine Venlafaxine Venlafaxine Dopamine Ascorbic acid Oxygen Dehydroascorbic acid Water L-Dopa Carbon dioxide L-Tyrosine Gq Signalling cascade