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Pathway Description
Ethanol Glycine Agonist Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-07-11
Last Updated: 2023-11-27
Ethanol, commonly seen in the form of various alcohols as well as hand sanitizer, is a drug that is injected intrathecally. Ethanol's effects are mainly seen in the brain where it binds to many receptors. The main effects are seen by the binding to GABA receptors, glycine receptors, and glutamate receptors.
Ethanol agonizes glycine receptors, where glycine binds to the alpha subunit. This causes an influx of chlorine ions which hyperpolarizes the neuron. Glycine receptors are present mainly in the spinal cord and brain stem where they control motor function. Therefore, the sedative effect of ethanol activating glycine receptors causes a decrease in motor control. Glycine can also activate GABA receptors if released into the same area, having the same effect on them as GABA.
References
Ethanol Glycine Agonist Pathway References
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Pubmed: 2155780
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Pubmed: 9674912
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Pubmed: 15302677
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Pubmed: 9676428
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Pubmed: 23238346
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Pubmed: 8898206
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