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Mitochondrial glycine transporter Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glycine Ethanol Ca+ Glycine Cl- Glycine Glycine Cl- Ca+ Glycine receptor subunit beta Glycine receptor subunit alpha-2 Hyperpolarization Glycine and Serine Metabolism Cytosol Mitochondria Presynaptic neuron Postsynaptic neuron Glycine is synthesized in a mitochondria located throughout the neuron. When the neuron is activated it is released into the synapse Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect, leading to impairment of motor control. Glycine binds to Glycine receptors on the alpha subunit. This causes the chloride channel to open, and the influx of chloride causes hyperpolarization in the neuron. Synapse Spinal Cord or Brain Stem Ethanol binds to Glycine receptors on the alpha-1 and alpha-2 subunits. This causes the channel to open more frequently which causes hyperpolarization in the neuron, decreasing the ability to depolarize. Synaptic Vesicle Cytosol Ethanol is injected intrathecally
Mitochondria SLC25A38 SLC32A1 CACNA1A Glycine Ethanol Calcium Glycine Chloride ion Glycine Glycine Chloride ion Calcium GLRB GLRA2 Hyperpolarization Glycine and Serine Metabolism
SLC25A38 SLC32A1 CACNA1A Gly Ethanol Ca+ Gly Cl- Gly Gly Cl- Ca+ GLRB GLRA2 Hyper PW000157 Cytosol Mitochondria Presynaptic neuron Postsynaptic neuron Glycine is synthesized in a mitochondria located throughout the neuron. When the neuron is activated it is released into the synapse Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect, leading to impairment of motor control. Glycine binds to Glycine receptors on the alpha subunit. This causes the chloride channel to open, and the influx of chloride causes hyperpolarization in the neuron. Synapse Spinal Cord or Brain Stem Ethanol binds to Glycine receptors on the alpha-1 and alpha-2 subunits. This causes the channel to open more frequently which causes hyperpolarization in the neuron, decreasing the ability to depolarize. Synaptic Vesicle Cytosol Ethanol is injected intrathecally
Mitochondria SLC25A38 SLC32A1 CACNA1A Gly Ethanol Ca2+ Gly Cl Gly Gly Cl Ca2+ GLRB GLRA2 Hyper PW000157