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Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit 3A Vesicular glutamate transporter 3 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutaminase kidney isoform, mitochondrial Ethanol L-Glutamic acid Ca+ L-Glutamic acid Ca+ L-Glutamine Ca+ L-Glutamic acid Ca+ H2O NH3 Depolarization Glutamate Metabolism Cytosol Ethanol binds to the Glutamate NMDA receptor subunit 3A which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron Blocking the Glutamate NMDA receptor prevents depolarization of the neuron that is caused by an influx of calcium. This is most commonly blocked in the hippocampus, preventing the formation of memories Presynaptic Neuron Hippocampus Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Glutamate would bind to the subunit epsilon-2 receptor, however since Ethanol bound to the glutamate receptor, glutamate is unable to bind in order to open the calcium channel so calcium is unable to enter the neuron Synaptic Vesicle Synapse Ethanol is injected intrathecally
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Ethanol L-Glutamic acid Calcium L-Glutamic acid Calcium L-Glutamine Calcium L-Glutamic acid Calcium Water Ammonia Depolarization Glutamate Metabolism
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Ethanol Glu Ca+ Glu Ca+ Gln Ca+ Glu Ca+ H2O NH3 Depol PW000003 Cytosol Ethanol binds to the Glutamate NMDA receptor subunit 3A which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron Blocking the Glutamate NMDA receptor prevents depolarization of the neuron that is caused by an influx of calcium. This is most commonly blocked in the hippocampus, preventing the formation of memories Presynaptic Neuron Hippocampus Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Glutamate would bind to the subunit epsilon-2 receptor, however since Ethanol bound to the glutamate receptor, glutamate is unable to bind in order to open the calcium channel so calcium is unable to enter the neuron Synaptic Vesicle Synapse Ethanol is injected intrathecally
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Ethanol Glu Ca2+ Glu Ca2+ Gln Ca2+ Glu Ca2+ H2O NH3 Depol PW000003