Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Myosin light chain kinase, smooth muscle Alpha-1A adrenergic receptor Myosin LC-P Myosin light chain 3 Serine/threonine- protein phosphatase PP1-beta catalytic subunit Calmodulin-1 Calmodulin-1 Inositol 1,4,5-trisphosphate Norepinephrine Ca+ Ca+ Ca+ Norepinephrine ATP Phosphatidylinositol 4,5-bisphosphate Ca+ Diacylglycerol Muscle Contraction Muscle Relaxation Calcium Magnesium Calcium Manganese Droxidopa is converted to norepinephrine via decarboxylation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Sarcoplasmic Reticulum Increased calcium binds readily to calmodulin to activate myosin light chain kinase There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Activation of myosin light chain kinase leads to high concentration of myosin LC-P which causes contractions of the muscles Vascular Smooth Muscle Cell Dilation Norepinephrine binds alpha-1 receptor. Actin Filament Myosin Filament Droxidopa is administered as an oral tablet
PRKCA CACNA1A CACNB1 CACNA2D2 GNAQ PLCB1 ITPR1 MYLK ADRA1A MYL3 MYL3 PPP1CB CALM1 CALM1 Inositol 1,4,5- trisphosphate Norepinephrine Calcium Calcium Calcium Norepinephrine Adenosine triphosphate Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Contraction Muscle Relaxation