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Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Myosin light chain kinase, smooth muscle Alpha-1A adrenergic receptor Myosin LC-P Myosin light chain 3 Myosin light chain phosphatase Calmodulin-1 Calmodulin-1 Inositol 1,4,5-trisphosphate Epinephrine Ca+ Ca+ Ca+ Epinephrine ATP Phosphatidylinositol 4,5-bisphosphate Ca+ Diacylglycerol Muscle Contraction Muscle Relaxation Calcium Magnesium Calcium Manganese Sarcoplasmic Reticulum Increased calcium binds readily to calmodulin to activate myosin light chain kinase There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Myosin binds to actin causing sarcomere filaments to slide closer resulting in muscle contraction Activation of myosin light chain kinase leads to high concentration of myosin LC-P which causes contractions of the muscles Vascular Smooth Muscle Cell Constriction Racepinephrine (Epinephrine) binds alpha-1 adrenergic receptor. Actin Filament Myosin Filament Racepinephrine is administered via respiratory inhalation
PRKCA CACNA1A CACNB1 CACNA2D2 GNAQ PLCB1 ITPR1 MYLK ADRA1A MYL3 MYL3 PPP1CB CALM1 CALM1 Inositol 1,4,5- trisphosphate Epinephrine Calcium Calcium Calcium Epinephrine Adenosine triphosphate Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Contraction Muscle Relaxation
PRKCA CACNA1A CACNB1 CACNA2D2 GNAQ PLCB1 ITPR1 MYLK ADRA1A MYL3 MYL3 PPP1CB CALM1 CALM1 Inotp Eppy Ca+ Ca+ Ca+ Eppy ATP P45P Ca+ Diacylg Mus Con Mus Rel Ca2+ Mg2+ Ca2+ Mn2+ Sarcoplasmic Reticulum Increased calcium binds readily to calmodulin to activate myosin light chain kinase There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Myosin binds to actin causing sarcomere filaments to slide closer resulting in muscle contraction Activation of myosin light chain kinase leads to high concentration of myosin LC-P which causes contractions of the muscles Vascular Smooth Muscle Cell Constriction Racepinephrine (Epinephrine) binds alpha-1 adrenergic receptor. Actin Filament Myosin Filament Racepinephrine is administered via respiratory inhalation