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Adenosine
receptor A2a
Gβ
Adenylate
cyclase type 10
Myosin light
chain kinase,
smooth muscle
Myosin LC-P
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Calmodulin-1
Myosin light
chain 3
Calmodulin-1
Gγ
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Guanine
nucleotide-
binding protein
G(s) subunit
alpha isoforms
short
Caffeine
cAMP
Ca
+
Ca
+
ATP
ATP
Magnesium
Ca
+
Muscle
Contraction
Magnesium
Calcium
Caffeine antagonizes
Adenosine A2A receptors in
blood vessels in the head
and neck.
cAMP inhibits myosin light
chain kinase, therefore the
low concentration of cAMP
allows myosin light chain
kinsase to be activated by
calmodulin so it can
phosphorylate myosin light
chain and cause muscle
contraction.
Smooth muscle contraction
causes vasoconstriction in
the arteries and veins in
the head and neck
Actin Filament
Myosin Filament
Vasoconstriction
Myosin and actin bind
allowing the filaments to
slide closer together,
resulting in muscle
contraction
ADORA2A
GNB1
ADCY10
MYLK
MYL3
CACNA1A
CACNA2D2
CALM1
MYL3
CALM1
GNG2
CACNB1
GNAS
Caffeine
cAMP
Calcium
Calcium
Adenosine
triphosphate
Adenosine
triphosphate
Calcium
Muscle
Contraction