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Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Chloride intracellular channel protein 2 Muscarinic acetylcholine receptor M1 Inositol 1,4,5-trisphosphate Ca+ Pilocarpine Ca+ Ca+ Cl- Cl- Pilocarpine Phosphatidylinositol 4,5-bisphosphate Calcium Diacylglycerol Sarcoplasmic Reticulum The opening of Cl- channels in the apical membrane of salivary gland acinar cells initiates the fluid secretion process There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Acinar Cell Pilocarpine is an agonist of the M1 muscarinic receptor Pilocarpine is administered as an oral capsule.
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 CLIC2 CHRM1 Inositol 1,4,5- trisphosphate Calcium Pilocarpine Calcium Calcium Chloride ion Chloride ion Pilocarpine Phosphatidylinositol 4,5- bisphosphate Diacylglycerol
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 CLIC2 CHRM1 Inotp Ca+ Pilocar Ca+ Ca+ Cl- Cl- Pilocar P45P Ca2+ Diacylg Sarcoplasmic Reticulum The opening of Cl- channels in the apical membrane of salivary gland acinar cells initiates the fluid secretion process There is an overall increase in calcium levels in the cytosol caused by the activation of the Gq signaling cascade Cytosol Acinar Cell Pilocarpine is an agonist of the M1 muscarinic receptor Pilocarpine is administered as an oral capsule.