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Gq protein
signaling
cascade
Phospholipase C
Inositol 1,4,5-
trisphosphate
receptor type 1
Protein kinase
C alpha type
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Chloride
intracellular
channel protein
2
Muscarinic
acetylcholine
receptor M1
Inositol 1,4,5-trisphosphate
Ca
+
Cevimeline
Ca
+
Ca
+
Cl
-
Cl
-
Cevimeline
Phosphatidylinositol
4,5-bisphosphate
Calcium
Diacylglycerol
Sarcoplasmic Reticulum
The opening of Cl- channels
in the apical membrane of
salivary gland acinar cells
initiates the fluid
secretion process
There is an overall increase
in calcium levels in the
cytosol caused by the
activation of the Gq
signaling cascade
Cytosol
Acinar Cell
Cevimeline is an agonist of
the M1 muscarinic receptor
Cevimeline is administered
as an oral capsule.
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
CLIC2
CHRM1
Inositol 1,4,5-
trisphosphate
Calcium
Cevimeline
Calcium
Calcium
Chloride ion
Chloride ion
Cevimeline
Phosphatidylinositol
4,5-
bisphosphate
Diacylglycerol
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
CLIC2
CHRM1
Inotp
Ca
+
Sni
Ca
+
Ca
+
Cl
-
Cl
-
Sni
P45P
Ca2+
Diacylg
Sarcoplasmic Reticulum
The opening of Cl- channels
in the apical membrane of
salivary gland acinar cells
initiates the fluid
secretion process
There is an overall increase
in calcium levels in the
cytosol caused by the
activation of the Gq
signaling cascade
Cytosol
Acinar Cell
Cevimeline is an agonist of
the M1 muscarinic receptor
Cevimeline is administered
as an oral capsule.