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Abciximab Cystatin-B Amino acids Bowman's Capsule Proximal Tubule Loop of Henle Distal Tubule Collecting Duct Abciximab is metabolized by the kidney, through glomerular filtration and extensive reactions that leads to either reabsorption or elimination of the byproducts Majority is broken down by proteases that are found throughout the kidney filtration system. Targeting majority of the Abciximab in the proximal tubule Glomerulus Lumen Blood The fragments of Abciximab are reduced to amino acids, which are then reabsorbed via the collecting duct to be used in de novo protein synthesis and other metabolic pathways. All additional byproducts in excess is excreted via urine Kidney
Unknown CSTB Amino acids