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Histamine H1 receptor Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Histidine decarboxylase Histamine Trimipramine Ca+ Histamine Histamine Ca+ Trimipramine Trimipramine L-Histidine CO2 Pyridoxal 5'-phosphate Depolarization Postsynaptic Neuron Cytosol Presynaptic Neuron Synaptic Vesicle Cytosol Tuberomammillary nucleus The depolarization of the tuberomammillary nucleus sends signals to all major areas of the brain and causes wakefulness. Therefore, the inhibition of histamine receptors causes sleepiness Diffusion
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Histamine Trimipramine Calcium Histamine Histamine Calcium Trimipramine Trimipramine L-Histidine Carbon dioxide Depolarization
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Hsm RP-7162 Ca+ Hsm Hsm Ca+ RP-7162 RP-7162 His CO2 Pyr-5'P Depol Postsynaptic Neuron Cytosol Presynaptic Neuron Synaptic Vesicle Cytosol Tuberomammillary nucleus The depolarization of the tuberomammillary nucleus sends signals to all major areas of the brain and causes wakefulness. Therefore, the inhibition of histamine receptors causes sleepiness Diffusion
HRH1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B HDC Hsm RP-7162 Ca2+ Hsm Hsm Ca2+ RP-7162 RP-7162 His CO2 Depol