Browsing Pathways
Showing 123781 -
123790 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0174757View Pathway |
Isoeugenol Predicted Metabolism PathwayMetabolites of Isoeugenol are predicted with biotransformer.
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SMP0143196View Pathway |
Isoflurane Drug Metabolism Action Pathway |
Drug Action
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SMP0126162View Pathway |
Isoflurane GABA(A) Anesthetic Action PathwayIsoflurane is an inhaled general anesthetic used in surgery. It can be found under the brand names Forane and Terrell and is a stable, non-explosive inhalation anesthetic, relatively free from significant side effects. Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by altering the activity of the channels that underlie the action potential. Isoflurane likely binds to GABA, glutamate and glycine receptors, but has different effects on each receptor. Isoflurane acts as a positive allosteric modulator of the GABAA receptor in electrophysiology studies of neurons and recombinant receptors. GABA-A receptors are predominantly on the post-synaptic membrane, and upon activation, open chloride channels to hyperpolarize the neuron and decreased firing rate. Potentiation of GABAergic neurons produces sedation. Isoflurane binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. Some side effects of using isoflurane may include anxiety, chest tightness, confusion, and shaking.
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Drug Action
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SMP0126409View Pathway |
Isoflurophate Action PathwayIsoflurophate is a cholinesterase inhibitor used to treat glaucoma, as it acts as a powerful miotic agent constricting the pupil and causing the aqueous fluid to flow out and relieve pressure. It acts by irreversibly binding to acetylcholinesterase and cholinesterase, inhibiting them from breaking down acetylcholine. Once isoflurophate binds to the enzymes it elicits parasympathomimetic effects, constricting the pupil and causing an outflow of fluid to drain out of the eye relieving the pressure caused by glaucoma. Due to irreversible binding, this damages the enzyme and can only be displaced by pralidoxime if it is administered prior to isoflurophate. If an overdose occurs some symptoms such as sweating, loss of bladder control, weakness, nausea, vomiting, diarrhea, cramps, stomach pains, shortness of breath, tight chest, wheezing, arrhythmias, fatigue or sudden salivation.
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Drug Action
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SMP0126686View Pathway |
Isoflurophate Action Pathway (new)Isoflurophate is a cholinesterase inhibitor used to treat glaucoma, as it acts as a powerful miotic agent constricting the pupil and causing the aqueous fluid to flow out and relieve pressure. It acts by irreversibly binding to acetylcholinesterase and cholinesterase, inhibiting them from breaking down acetylcholine. Once isoflurophate binds to the enzymes it elicits parasympathomimetic effects, constricting the pupil and causing an outflow of fluid to drain out of the eye relieving the pressure caused by glaucoma. Due to irreversible binding, this damages the enzyme and can only be displaced by pralidoxime if it is administered prior to isoflurophate. If an overdose occurs some symptoms such as sweating, loss of bladder control, weakness, nausea, vomiting, diarrhea, cramps, stomach pains, shortness of breath, tight chest, wheezing, arrhythmias, fatigue or sudden salivation.
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Drug Action
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SMP0130688View Pathway |
Isoflurophate Drug MetabolismIsoflurophate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Isoflurophate passes through the liver and is then excreted from the body mainly through the kidney.
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SMP0143121View Pathway |
Isoflurophate Drug Metabolism Action Pathway |
Drug Action
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SMP0144079View Pathway |
Isometheptene Drug Metabolism Action Pathway |
Drug Action
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SMP0174807View Pathway |
Isometheptene Predicted Metabolism PathwayMetabolites of Isometheptene are predicted with biotransformer.
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SMP0130678View Pathway |
Isoniazid Drug MetabolismIsoniazid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Isoniazid passes through the liver and is then excreted from the body mainly through the kidney.
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Showing 123781 -
123790 of 131547 pathways