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Pathway Description
Metabolism and Physiological Effects of Xanthosine
Homo sapiens
Metabolic Pathway
Created: 2021-10-19
Last Updated: 2023-10-25
Xanthosine is formed from purine catabolism. Purines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. These undergo metabolism in the liver to form xanthosine.
Adenine forms adenosine through the enzyme purine nucleoside phosphorylase. Adenosine then reacts with water to form inosine and ammonia using the enzyme adenosine deaminase. Inosine goes on to form hypoxanthine through the enzyme purine nucleoside phosphorylase. Xanthine is formed from hypoxanthine using the enzyme xanthine dehydrogenase/ oxidase. Xanthine can also be formed from the purine guanine via guanine deaminase. Xanthine is then converted to xanthosine via the enzyme purine nucleoside phosphorylase. Xanthosine then enters the blood where it can have detrimental effects on other organs such as the kidney, causing renal failure and the heart causing cardiovascular disease.
References
Metabolism and Physiological Effects of Xanthosine References
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