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Lanosterol 14-alpha demethylase Solute carrier organic anion transporter family member 2B1 Ergosterol is essential in maintaining membrane integrity. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Itraconazole 4,4-Dimethylcholesta- 8,14,24-trienol Ergosterol Itraconazole Lanosterol O2 NADPH Formic acid H+ H2O NADP Steroid Biosynthesis Heme Fungal yeast cell Bud of Fungus Cell Blood Vessel Human Cell Itraconazole works better on Candida Glabrata which is more likely to be present in immunocompromised people. Fungal yeast cell Itraconazole binds to lanosterol 14-alpha demethylase, which inhibits the production of 4,4-Dimethylcholesta- 8,14,24-trienol which is essential in production of lipids to make more fungal cell membrane Endoplasmic Reticulum
Endoplasmic Reticulum ERG11 SLCO2B1 Itraconazole 4,4- Dimethylcholesta- 8,14,24- trienol Ergosterol Itraconazole Lanosterol Oxygen NADPH Formic acid Hydrogen Ion Water NADP Steroid Biosynthesis
ERG11 SLCO2B1 Ergosterol is essential in maintaining membrane integrity. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Itc FF-Mas Ergoste Itc Lastrol O2 NADPH Formate H+ H2O NADP PW126640 Heme Fungal yeast cell Bud of Fungus Cell Blood Vessel Human Cell Itraconazole works better on Candida Glabrata which is more likely to be present in immunocompromised people. Fungal yeast cell Itraconazole binds to lanosterol 14-alpha demethylase, which inhibits the production of 4,4-Dimethylcholesta- 8,14,24-trienol which is essential in production of lipids to make more fungal cell membrane Endoplasmic Reticulum
Endoplasmic Reticulum ERG11 SLCO2B1 Itc FF-Mas Ergoste Itc Lastrol O2 NADPH Formate H+ H2O NADP PW126640