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Hydroxycarboxylic acid receptor 2 Adenylate cyclase type 9 Lanosterol 14-alpha demethylase Adiponectin Adiponectin Clotrimazole Clotrimazole Clotrimazole 4,4-Dimethylcholesta- 8,14,24-trienol cAMP ATP Lanosterol O2 NADPH Formic acid H+ H2O NADP Steroid Biosynthesis (Not This One) Lipolysis Insulin Signalling Ergosterol Magnesium Heme Fungal yeast cell Bud of Fungus Cell Clotrimazole inhibits the production of ergosterol by inhibiting and antagonizing Lanosterol 14-alpha demethylase Candida albicans cell or Malassezia furfur cell Clotrimazole is applied topically to the infected area Clotrimazole inhibits Ergosterol by binding to it in the cell membrane, creating a transmembrane channel that increases cell permiability allowing leakage of cellular components. Eventually this compromises cell integrity and causes cell death Adipose cell Adiponectin travels to the liver and skeletal muscles where it causes insulin resistance in the cells The Hydroxycarboxylic acid receptor inhibits adenylyl cyclase which prevents the adipose cell from synthesizing cAMP which prevents lypolysis. (The synthesis of glycerol and 3-fatty acids) Clotrimazole is a partial agonist to Hydroycarboxylic acid receptor 2. Endoplasmic Reticulum
Endoplasmic Reticulum HCAR2 ADCY9 ERG11 ADIPOQ ADIPOQ Clotrimazole Clotrimazole Clotrimazole 4,4- Dimethylcholesta- 8,14,24- trienol cAMP Adenosine triphosphate Lanosterol Oxygen NADPH Formic acid Hydrogen Ion Water NADP Steroid Biosynthesis (Not This One) Lipolysis Insulin Signalling Ergosterol
Endoplasmic Reticulum HCAR2 ADCY9 ERG11 ADIPOQ ADIPOQ Gynix Gynix Gynix FF-Mas cAMP ATP Lastrol O2 NADPH Formate H+ H2O NADP PW126623 Lipol PW000454 Ergoste