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Lanosterol 14-alpha demethylase Isoconazole 4,4-Dimethylcholesta- 8,14,24-trienol Isoconazole Lanosterol O2 NADPH Formic acid H+ H2O NADP Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Ergosterol Steroid Biosynthesis Heme Fungal yeast cell Bud of Fungus Cell Isoconazole, like other imidazoles, inhibits the production of ergosterol by inhibiting Lanosterol 14-alpha demethylase Isoconazole is applied topically to the infected area which is commonly used for superficial skin or the vagina. Endoplasmic Reticulum Fungal Cell
Endoplasmic Reticulum ERG11 Isoconazole 4,4- Dimethylcholesta- 8,14,24- trienol Isoconazole Lanosterol Oxygen NADPH Formic acid Hydrogen Ion Water NADP Ergosterol Steroid Biosynthesis
ERG11 Isoco FF-Mas Isoco Lastrol O2 NADPH Formate H+ H2O NADP Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells Ergoste PW127409 Heme Fungal yeast cell Bud of Fungus Cell Isoconazole, like other imidazoles, inhibits the production of ergosterol by inhibiting Lanosterol 14-alpha demethylase Isoconazole is applied topically to the infected area which is commonly used for superficial skin or the vagina. Endoplasmic Reticulum Fungal Cell