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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Flumazenil L-Glutamic acid γ-Aminobutyric acid Ca+ Flumazenil Cl- Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Depolarization Depolarization leading to increased excitability. Increasing neuronal excitability combats the sedative effects of benzodiazepines. Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA(A) receptor site is competitively inhibited by Flumazenil. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site. It targets the gamma-2, alpha-1, and alpha-5 subunits. Cytosol Cytosol Synapse Flumazenil is administered via intravenous injection
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Flumazenil L-Glutamic acid γ-Aminobutyric acid Calcium Flumazenil Chloride ion Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Depolarization
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Anexate Glu GABA Ca+ Anexate Cl- Cl- CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Depol Depolarization leading to increased excitability. Increasing neuronal excitability combats the sedative effects of benzodiazepines. Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA(A) receptor site is competitively inhibited by Flumazenil. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site. It targets the gamma-2, alpha-1, and alpha-5 subunits. Cytosol Cytosol Synapse Flumazenil is administered via intravenous injection
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca2+ Anexate Glu GABA Ca2+ Anexate Cl Cl CO2 ATP Ppi Gi/ sig PW000003 Depol