Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Protein kinase A Protein kinase A D(2) dopamine receptor Adenylate cyclase type 2 Guanine nucleotide- binding protein G(i) subunit alpha-1 Synaptic vesicular amine transporter Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent N-type calcium channel subunit alpha-1B Sodium- dependent dopamine transporter Solute carrier family 22 member 5 Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase cAMP Ca+ Dopamine Dopamine Pramipexole Dopamine Ca+ Pramipexole Pramipexole L-Tyrosine L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyridoxal 5'-phosphate Neuronal Excitability Magnesium Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Pramipexole is an agonist at D2 and D3 receptors Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Prefrontal Cortex Synapse Blood vessel - Blood Brain Barrier Brain
PRKAR1A PRKAR1B DRD2 ADCY2 GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 SLC22A5 TH DDC cAMP Calcium Dopamine Dopamine Pramipexole Dopamine Calcium Pramipexole Pramipexole L-Tyrosine L-Dopa Carbon dioxide Adenosine triphosphate Pyrophosphate Sodium Sodium Neuronal Excitability
PRKAR1A PRKAR1B DRD2 ADCY2 GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 SLC22A5 TH DDC cAMP Ca+ LDP LDP Pramipe LDP Ca+ Pramipe Pramipe Tyr L-Dopa CO2 ATP PPi Na+ Na+ Fe2+ Pyr-5'P Neu Exc Mg2+ Activation of D2 dopamine receptors activates the Gi signalling cascade which leads to increased cAMP. Pramipexole is an agonist at D2 and D3 receptors Presynaptic Neuron Cytosol Synaptic Vesicle Postsynaptic Neuron Cytosol Dopamine is produced in the Ventral Tegmental Area of the brain Prefrontal Cortex Synapse Blood vessel - Blood Brain Barrier Brain
PRKAR1A PRKAR1B DRD2 ADCY2 GNAI1 SLC18A2 CACNA2D1 CACNA2D2 CACNA1B SLC6A3 SLC22A5 TH DDC cAMP Ca2+ LDP LDP Pramipe LDP Ca2+ Pramipe Pramipe Tyr L-Dopa CO2 ATP Ppi Na+ Na+ Neu Exc