SMPDB

Showing 49661 - 49670 of 605359 pathways

SMPDB ID	Pathway Name and Description	Pathway Class	Chemical Compounds	Proteins
SMP0145106 View Pathway	Propylparaben Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Propylparaben
SMP0145111 View Pathway	Geraniol Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Geraniol
SMP0145113 View Pathway	Aripiprazole lauroxil Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Aripiprazole lauroxil
SMP0145118 View Pathway	p-tert-Butylphenol-formaldehyde resin (low molecular weight) Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	p-tert-Butylphenol-formaldehyde resin (low molecular weight)
SMP0145099 View Pathway	Synthetic camphor Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Synthetic camphor
SMP0145413 View Pathway	Cyproheptadine H1 Antihistamine Neurological Sleep Action Pathway Cyproheptadine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Wakefulness is regulated by histamine in the tuberomammillary nucleus, a part of the hypothalamus. Histidine is decarboxylated into histamine in the neuron. Histamine is transported into synaptic vesicles by a monoamine transporter then released into the synapse. Normally histamine would activate the H1 histamine receptor on the post-synaptic neuron in the tuberomammillary nucleus. Cyproheptadine inhibits the H1 histamine receptor, preventing the depolarization of the post-synaptic neuron. This prevents the wakefulness signal from being sent to the major areas of the brain, causing sleepiness. BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Calcium Carbon dioxide Cyproheptadine Histamine L-Histidine Pyridoxal 5'-phosphate ( show all show less )	Histamine H1 receptor Histidine decarboxylase Synaptic vesicular amine trans... Voltage-dependent calcium chan... Voltage-dependent calcium chan... Voltage-dependent N-type calci... ( show all show less )
SMP0145418 View Pathway	Cyclizine H1 Antihistamine Neurological Sleep Action Pathway Cyclizine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Wakefulness is regulated by histamine in the tuberomammillary nucleus, a part of the hypothalamus. Histidine is decarboxylated into histamine in the neuron. Histamine is transported into synaptic vesicles by a monoamine transporter then released into the synapse. Normally histamine would activate the H1 histamine receptor on the post-synaptic neuron in the tuberomammillary nucleus. Cyclizine inhibits the H1 histamine receptor, preventing the depolarization of the post-synaptic neuron. This prevents the wakefulness signal from being sent to the major areas of the brain, causing sleepiness. BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Calcium Carbon dioxide Cyclizine Histamine L-Histidine Pyridoxal 5'-phosphate ( show all show less )	Histamine H1 receptor Histidine decarboxylase Synaptic vesicular amine trans... Voltage-dependent calcium chan... Voltage-dependent calcium chan... Voltage-dependent N-type calci... ( show all show less )
SMP0145383 View Pathway	Fluoride ion Drug Metabolism Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Fluoride ion
SMP0145394 View Pathway	Nomifensine Drug Metabolism Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Nomifensine
SMP0145388 View Pathway	Clobetasol Drug Metabolism Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Clobetasol