SMPDB

Showing 123281 - 123290 of 605359 pathways

SMPDB ID	Pathway Name and Description	Pathway Class	Chemical Compounds	Proteins
SMP0144714 View Pathway	Indigotindisulfonic acid Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indigotindisulfonic acid
SMP0125928 View Pathway	Indinavir Action Pathway Indinavir is a protease inhibitor used to treat HIV infection. The HIV virus binds and penetrates the host cell. Viral RNA is transcribed into viral DNA via reverse transcriptase. Viral DNA enters the host nucleus and is integrated into the host DNA via integrase. The DNA is then transcribed, creating viral mRNA. Viral mRNA is translater into the gag-pol polyprotein. HIV protease is synthesized as part of the Gag-pol polyprotein, where Gag encodes for the capsid and matrix protein to form the outer protein shell, and Pol encodes for the reverse transcriptase and integrase protein to synthesize and incorporate its genome into host cells. HIV-1 protease cleaves the Gag-pol polyprotein into 66 molecular species, including HIV-1 protease, integrase, and reverse transcriptase. Indinavir competitively binds to the active site of HIV-1 protease. This inhibition prevents the HIV virion from fully maturing and becoming infective. Using the lipid bilayer of the host cell, a virus is formed and released. The inhibition of HIV-1 protease prevents the necessary molecular species from forming, therefore preventing maturation and activation of viral particles. This forms immature, non-infectious viral particles, therefore, Indinavir prevents the virus from reproducing. BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indinavir Magnesium	Gag-Pol polyprotein HIV-1 protease Integrase Reverse transcriptase protein Reverse transcriptase/RNaseH
SMP0142686 View Pathway	Indinavir Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indinavir
SMP0144502 View Pathway	Indium In-111 chloride Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indium In-111 chloride
SMP0128143 View Pathway	Indium In-111 imciromab pentetate Drug Metabolism BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic		Cystatin-B Indium In-111 imciromab pentet...
SMP0130676 View Pathway	Indium In-111 oxyquinoline Drug Metabolism Indium In-111 oxyquinoline is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Indium In-111 oxyquinoline passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Indium In-111 oxyquinoline	Solute carrier organic anion t...
SMP0144493 View Pathway	Indium In-111 oxyquinoline Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indium In-111 oxyquinoline
SMP0130595 View Pathway	Indium In-111 pentetate Drug Metabolism Indium In-111 pentetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Indium In-111 pentetate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Metabolic	Indium In-111 pentetate	Solute carrier organic anion t...
SMP0144484 View Pathway	Indium In-111 pentetate Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indium In-111 pentetate
SMP0144792 View Pathway	Indium In-111 pentetreotide Drug Metabolism Action Pathway BioPAX SVG SBGN SBML PWML All files (.zip)	Drug Action	Indium In-111 pentetreotide