Browsing Pathways
Showing 123291 -
123300 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0130870View Pathway |
Indocyanine green acid form Drug MetabolismIndocyanine green acid form is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Indocyanine green acid form passes through the liver and is then excreted from the body mainly through the kidney.
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SMP0144452View Pathway |
Indocyanine green acid form Drug Metabolism Action Pathway |
Drug Action
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SMP0130714View Pathway |
Indocyanine green Drug MetabolismIndocyanine green is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Indocyanine green passes through the liver and is then excreted from the body mainly through the kidney.
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SMP0145285View Pathway |
Indocyanine green Drug Metabolism Action Pathway |
Drug Action
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SMP0125880View Pathway |
Indole pyruvate decomposition |
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SMP0000104View Pathway |
Indomethacin Action PathwayIndomethacin (also named Amuno or Indocid) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation. Indomethacin can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased prostaglandin synthesis is caused by presence of indomethacin.
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Drug Action
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SMP0142787View Pathway |
Indomethacin Drug Metabolism Action Pathway |
Drug Action
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SMP0124592View Pathway |
Indomethacin NSAID Action Pathway
Indomethacin is a nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. It has analgesic, antipyretic and anti-inflammatory effects. It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2. The rest of the pathway occurs on the endoplasmic reticulum membrane, where prostaglandin G/H synthase 1 & 2 converts arachidonic acid into prostaglandin H2. Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase or prostaglandin E2 via prostaglandin E synthase. COX-2 is an inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation of prostaglandin E2 which is responsible for contributing to the inflammatory response by activating immune cells and for increasing pain sensation by acting on pain fibers. Indomethacin inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2). The low concentration of prostaglandin E2 attenuates the effect it has on stimulating immune cells and pain fibers, consequently reducing inflammation and pain. Fever is triggered by inflammatory and infectious diseases. Cytokines are produced in the central nervous system (CNS) during an inflammatory response. These cytokines induce COX-2 production that increases the synthesis of prostaglandin, specifically prostaglandin E2 which adjusts hypothalamic temperature control by increasing heat production. Because indomethacin decrease PGE2 in the CNS, it has an antipyretic effect.
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Drug Action
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SMP0174401View Pathway |
Indomethacin Predicted Metabolism Pathway newMetabolites of Indomethacin are predicted with biotransformer.
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SMP0144238View Pathway |
Indoramin Drug Metabolism Action Pathway |
Drug Action
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Showing 123291 -
123300 of 131501 pathways