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Matched Description: of the MRs such as aldosterone, cortisol, and 11-deoxycorticosterone; preventing receptor activation … in the zone glomerulosa. Aldosterone acts on receptors in collecting and distal tubules of the … nephron causing increased reabsorption of Na+ and increased secretion of K+. Aldosterone binds to … stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in … help in reducing inflammation, fibrosis, and improving proteinuria, along with severe congestive

Matched Compounds: Aldosterone

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone … (+)-aldosterone

Matched Description: Phenylketonuria, also called Folling disease, is a rare inborn error of metabolism (IEM) and … disorder is characterized by a large accumulation of phenylalanine in the blood and other tissues. It is … , Phenylacetylglutamine, and Glycine in the blood and urine. Symptoms of the disorder include behavioural … problems, psychiatric disorders and seizures. Treatment eating a diet limiting the intake of

Matched Proteins: Sodium- and chloride-dependent creatine transporter 1

Matched Compound Synonyms: 2-oxo-3-phenylpropanoic acid (mixture oxo and keto) … Ammonia (conc 20% or greater) … [oh(oh)] … Ammonia (conc 20% or greater) … [oh(oh)]

Matched Description: Ibuprofen is a very common NSAID drug used to treat pain and inflammation. This includes headaches … , muscle pain and fever. It is sold under the brand name Advil or Motrin. Ibuprofen is typically … prostaglandin G/H synthase (COX). These enzymes are available as COX1 and COX2, and are encoded by … PTGS1 (COX1) and PTGS2 (COX2). Ibuprofen may also inhibit fatty acid amide hydrolase (FAAH), which

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-leukotriene b4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-ltb4 … 20-carboxy-leukotriene b4

Matched Description: The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of … Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. Sodium … and bicarbonate (hydrogen carbonate) are transported by a co-transporter that is responsible for the … and apical membranes, respectively, to effectively regulate the pH of the filtrate. In addition … occurrence explains solute movement secondary to water flow. All the cation and anion transport

Matched Proteins: Sodium- and chloride-dependent transporter XTRP3 … Neutral and basic amino acid transport protein rBAT

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter … Solute carrier family 6 member 20 … Water channel protein for red blood cells and kidney proximal tubule … Water channel protein for red blood cells and kidney proximal tubule

Matched Compound Synonyms: [co2(oh)](-) … [co2(oh)](-) … [co2(oh)](-)

Matched Description: -steroidal anti-inflammatory drug (NSAID). It is used to treat pain and inflammation in many conditions … (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase … , and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation … immune cells and for increasing pain sensation by acting on pain fibers. Dexibuprofen inhibits the … action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of

Matched Compound Synonyms: Fa(20:4(5z,8z,11z,14z)) … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability. … proposed to be more pharmacologically active and tolerable with a better safety profile than … the simulated gastric and enteric juices compared with the racemic ibuprofen and displays improved oral bioavilability.

Matched Description: production of aldosterone which increases salt and water retention which increases blood volume. Less … vasoconstrictive effects and increases blood pressure. Quinapril is used to treat hypertension, high blood … pressure, congestive heart failure, and chronic renal failure as it decreases blood pressure … angiotensin II type 1 receptor (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary … angiotensin II reduces aldosterone production allowing water retention to not increase. AT1 receptors in

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: and water retention which increases blood volume. Blocking AT1 receptors reduces aldosterone … that has powerful vasoconstrictive effects and increases blood pressure. Forasartan used to treat … receptors (AT1) in blood vessels, kidneys, hypothalamus, and posterior pituitary. In blood vessels AT1 … . AT1 receptors in the kidney are responsible for the production of aldosterone which increases salt

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: II. By inhibiting those actions, saprosartan leads to a decrease in sodium reabsorpion and a decrease

Matched Compounds: Aldosterone

Matched Protein Synonyms: Neuronal and epithelial glutamate transporter

Matched Compound Synonyms: (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: release of aldosterone from the adrenal cortex and release of vasopressin from the posterior pituitary … circulation at the collecting duct via potassium and sodium channels. However, aldosterone is a major … The collecting duct of the nephron is the last segment of the functioning nephron and is connected … to minor calyces and the ensuing renal pelvis of the kidney where urine continues before it is … stored in the bladder. The collecting duct is mainly responsible for the excretion and reabsorption of

Matched Compounds: Aldosterone

Matched Compound Synonyms: [co2(oh)](-) … (+)-aldosterone … D-aldosterone … Delta-aldosterone … Aldosterone

Matched Description: (NSAID). It can be used to treat pain, fever and inflammation. Salsalate can block prostaglandin … synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 … and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to

Matched Compounds: 20-Hydroxy-leukotriene B4 … 20-Carboxy-leukotriene B4 … 20-Hydroxyeicosatetraenoic acid … PC(14:0/20:4(5Z,8Z,11Z,14Z))

Matched Protein Synonyms: Leukotriene-B(4) 20-monooxygenase 1 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20 … Cytochrome P450 MP-20

Matched Compound Synonyms: 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoate … 20-oh-ltb4 … 20-oh-5s,12s-dihydroxy-6,10-trans-8,14-cis-eicosatetraenoic acid … 20-oh-leukotriene b4 … 20-hydroxy arachidonic acid